Nitroprusside cyanide toxicity
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Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions.
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An early manifestation of cyanide toxicity is increasing dosage requirements to maintain blood pressure control. Metabolic acidosis may not be evident for more than an hour after toxic cyanide levels accumulate. If cyanide toxicity develops, discontinue sodium nitroprusside, and consider specific treatment of cyanide toxicity [see Overdosage
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Cyanide poisoning, cyanide toxicity, hydrocyanic acid poisoning. ไอออนของ ↑ Sodium Nitroprusside. The American Society of Health-System
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Nitroprusside: Nitroprusside is metabolized to cyanide, and it can lead to cyanide toxicity. Toxicity can appear as little as four hours after initiation of infusion. Potential risk factors for the development of toxicity are underlying renal impairment, prolonged treatment period (over 48 hours), and the utilization of a higher dose.
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Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions.
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Warnings: Excessive hypotension and cyanide toxicity are significant risks of nitroprusside Treatment of cyanide toxicity: Discontinue sodium nitroprusside
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by MR Holme 2024 Cited by 23Toxicity 1. Cyanide toxicity: Nitroprusside combines with hemoglobin and is subsequently metabolized to 5 cyanide ions and cyanmethemoglobin.
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Toxicity. The toxicity of nitroprusside is related to its potent antihypertensive effects and the accumulation of toxic metabolites (cyanide, thiocyanate, and methemoglobin). 1. Cyanide toxicity: Nitroprusside combines with hemoglobin and is subsequently metabolized to 5 cyanide ions and cyanmethemoglobin. Cyanide then converts to thiocyanate
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So, nitroprusside can only be administered no more than H why? cause cyanide toxicity, how does it happen? well nitroprusside breakdown
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