The co-expression of endocrine receptors and HER2, albeit associated with resistance to hormonal and anti-HER2 therapy, resulting in worse prognosis, creates an opportunity of combination treatment, consisting of anti-HER2 drugs and ET, in particular when dual HER2-blockade is used.
HER2-induced breast cancer development and enhances HER2-targeted therapy The synergy scores for multiple drug combinations in HER2
HER2-positive tumors. All breast cancers are tested for HER2 status to help guide treatment. If a tumor is HER2-positive, the HER2-targeted therapy drug trastuzumab (Herceptin) is included in the chemotherapy regimen. Sometimes other drugs that target HER2 are used.
All breast cancers are tested for HER2 status to help guide treatment. If a tumor is HER2-positive, the HER2-targeted therapy drug trastuzumab (Herceptin) is included in the chemotherapy regimen. Sometimes other drugs that target HER2 are used. Learn more about trastuzumab and other HER2-targeted therapies for early breast cancer.
Trastuzumab, was the first HER2-targeted drug for breast cancer. Based on this, two anti-HER2 ADCs have been developed and approved by the FDA for HER2-
HER2-positive breast cancers have a lot of a protein called HER2 on the surface of their cells. The HER2 protein is an important driver of cell growth and survival. HER2-targeted therapies are used to treat HER2-positive breast cancers. They have no role in the treatment of HER2-negative cancers. Testing for HER2 status
In addition, new anti-HER2 therapies, either as monotherapy or combined with trastuzumab, have demonstrated anti-HER2 tumor activity. 270,271 Single anti-HER2 drugs appear to be mild but with
If a tumor is HER2-positive, the HER2-targeted therapy drug trastuzumab (Herceptin) is included in the chemotherapy regimen. Sometimes other drugs that target
HER2-targeted therapies and HER2-positive breast cancer. HER2-positive breast cancers have a lot of a protein called HER2 on the surface of their cells. The HER2 protein is an important driver of cell growth and survival. HER2-targeted therapies are designed to treat HER2-positive breast cancers.
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