Acyclovir and valacyclovir work similarly. However, valacyclovir has more bioavailability and a longer half-life than acyclovir. As such, one
The half-life and total body clearance of acyclovir are dependent on renal function as shown in Table 2. Table 2: Acyclovir Half-life and plasma half-life of
Mean effective half-life: The half-life for valacyclovir is short, about 30 minutes. However, it converts to acyclovir, which has a half-life of 2.5 to 3.3 hours in those with normal renal (kidney) function. Time to steady-state: 38 weeks for acyclovir.
conversion of valacyclovir to acyclovir is reduced, and the acyclovir half- life is not affected. Dosage modification is not recommended for patients with
Acyclovir and valacyclovir work similarly. However, valacyclovir has more bioavailability and a longer half-life than acyclovir. As such, one
Acyclovir and valacyclovir work similarly. However, valacyclovir has more bioavailability and a longer half-life than acyclovir. As such, one
Following administration of valacyclovir to subjects with ESRD, the average acyclovir half-life is approximately 14 hours. During hemodialysis, the acyclovir half-life is approximately 4 hours. Approximately one-third of acyclovir in the body is removed by dialysis during a 4-hour hemodialysis session.
Following administration of valacyclovir tablets to subjects with ESRD, the average acyclovir half-life is approximately 14 hours. During hemodialysis, the acyclovir half-life is approximately 4 hours. Approximately one-third of acyclovir in the body is removed by dialysis during a 4-hour hemodialysis session.
Following administration of valacyclovir to subjects with ESRD, the average acyclovir half-life is approximately 14 hours. During hemodialysis, the acyclovir half-life is approximately 4 hours. Approximately one-third of acyclovir in the body is removed by dialysis during a 4-hour hemodialysis session.
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