Conclusions: The magnitude of the amiodarone/warfarin interaction is highly dependent on the maintenance dose of amiodarone. This relationship can aid clinicians in adjusting the dose of warfarin patients receiving long-term amiodarone treatment. (CHEST 2024; 1 23) Key words: amiodarone; drug/drug interaction; warfarin
Amiodarone is purported to interact with warfarin by inhibiting CYP and displacing warfarin from protein-binding sites. 16, 17 Warfarin exists as S- and R-stereoisomers. 8 Unlike the case with other warfarin drug drug interactions, amiodarone s interaction with warfarin occurs with either warfarin isomer. 16 Warfarin is metabolized by CYP
by M Naganuma 2024 Cited by 54metabolite of amiodarone, plays an important role in the interaction of warfarin and amiodarone. Key words: amiodarone, desethylamiodarone, warfarin
Due to the long half life of amiodarone, interactions - warfarin. The combination of warfarin with amiodarone may exacerbate the effect of the oral
by M Naganuma 2024 Cited by 54metabolite of amiodarone, plays an important role in the interaction of warfarin and amiodarone. Key words: amiodarone, desethylamiodarone, warfarin
See the list of drugs that interact with Amiodarone. Includes information on severity of interaction and the level of evidence for it. Warfarin. Amiodarone
Warfarin Drug Interactions Amiodarone 400 mg/day: Reduce Warfarin dose 40% Amiodarone 300 mg/day: Reduce Warfarin dose 35% Amiodarone 200 mg/
warfarin and amiodarone, J Clin Pharmacol, № 50, с. 693 Lu, Characteristics of the amiodarone-warfarin interaction
interactions may be slow after initiating amiodarone, and interactions Warfarin: Amiodarone increases the blood thinning effect of Warfarin.
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