omeprazole with methotrexate (primarily at high dose) There are no clinical data on the effects of omeprazole or sodium bicarbonate on the breastfed infant or
Omeprazole enters human breast milk, but the relative infant dose approximates 1.1%. Further, omeprazole is acid labile. Virtually all of the omeprazole ingested would probably be destroyed in the stomach. Thus the nursing infant is unlikely to ingest a clinically significant amount. Drug Interactions
Omeprazole Dosing Omeprazole is a proton pump inhibitor it is a prodrug and requires activation in acid Efficacy and safe Metabolism Pharmacokinetics Drug-interaction Treatment Breast-milk Infants Children Research Article Clinical Pharmacology of Omeprazole in Infants and Children Gian Maria Pacifici
Omeprazole enters human breast milk, but the relative infant dose approximates 1.1%. Further, omeprazole is acid labile. Virtually all of the omeprazole ingested would probably be destroyed in the stomach. Thus the nursing infant is unlikely to ingest a clinically significant amount. Drug Interactions
This article on PPI dosing in infants . lansoprazole doses of omeprazole than adults due to different pharmacokinetics of omeprazole in children.
Infants were given omeprazole 0.7 mg/kg daily for 7 days and then Dose-Finding Study of Omeprazole on Gastric pH in Neonates with
were used: omeprazole dosing infants, children, omeprazole International Pediatric Omeprazole Study Group. J Pediatr. 2024; 137: 800
omeprazole with methotrexate (primarily at high dose) There are no clinical data on the effects of omeprazole or sodium bicarbonate on the breastfed infant or
Omeprazole Dosing Omeprazole is a proton pump inhibitor it is a prodrug and requires activation in acid Efficacy and safe Metabolism Pharmacokinetics Drug-interaction Treatment Breast-milk Infants Children Research Article Clinical Pharmacology of Omeprazole in Infants and Children Gian Maria Pacifici
Hence Omeprazole being a much more expensive drug than it is now.....